For perfect high-performance liquid chromatography (HPLC) results, high-performance solvents are a must. LiChrosolv® solvents from Merck are designed to optimally support analytical HPLC, fast chromatography, and LC-MS applications.

Using LiChrosolv® solvents, you benefit from high resolution and sensitivity as well as optimized peak baseline separation. They feature high degrees of UV transmittance, low particle counts, low acidity and alkalinity, and low evaporation residue levels making them ideal for reproducible separations. All our LiChrosolv® solvents are microfiltered at 0.2 µm for your convenience.

For analytical HPLC, we provide LiChrosolv® solvents in ‘isocratic grade’ and ‘gradient grade’. Gradient grade LiChrosolv® solvents enable you to minimize the gradient effect of the solvent involved – for example in enantiomeric separations on chiral phases – and are suitable for UPLC and UHPLC.

For fast chromatography and LC-MS detection, Merck offers LiChrosolv® hypergrade, a family of solvents especially optimized and tested for LC-MS suitability. LiChrosolv® hypergrade solvents meet all the requirements of modern LC-MS ionization methods (ESI/ APCI – positive and negative mode). Due to their low level of ionic background and low ion suppression, LiChrosolv® hypergrade solvents ensure high reproducibility and high ionization efficiency.